
Last Updated
Current


Description
An interaction between two proteins.
Properties
methods - IntAct method(s) for determining interaction with ID and name (ex ["MI:0007"(anti tag coimmunoprecipitation),..]). VirHost method(s) with name (ex [(two hybrid),...]).
types - IntAct interaction type(s) with ID and name (ex ["MI:0915"(physical association),..]). VirHost interaction type(s) with name (ex [(physical association),...]).
miscores - The MIscore normalized score calculates a composite score for an interaction based on the number of publications reporting the interaction, the reported interaction detection methods and interaction types. (IntAct and/or VirHost depending on sources)
is_directed - IntAct edges can be directed
roleA - Role of start protein (ex [enzyme]) (IntAct)
roleB - Role of end protein (ex [enzyme target]) (IntAct)
domainInteraction - True if domain interaction (ProtCID)
experiments_score - All interaction records from the IMEx databases (plus BioGRID), are re-mapped and re-processed: first, duplicate records and datasets are removed, and then entire groups of records are benchmarked against KEGG and scored accordingly. (1; STRING)
textmining_score - Statistical co-citation analysis across a large number of scientific texts, including all PubMed abstracts as well as OMIM (1; STRING)
databases_score - Manually curated interaction records assembled by expert curators, at KEGG, Reactome, BioCyc and Gene Ontology, as well as legacy datasets from PID and BioCarta. (1; STRING)
score - Total score using all STRING scores
neighborhood_score - Gene neighborhood based interaction prediction (1, 2; STRING)
coexpression_score - Generated from gene-by-gene correlation tests across a large number of gene expression datasets (using both transcriptome measurements as well as proteome measurements). (1; STRING)
cooccurrence_score - Co-occurrence of pairs of genes across multiple genomes used for interaction prediction (1, 2; STRING)
exp_score - Combined known interactions score using database and experimental STRING scores
fusion_score - Fusion events used for interaction prediction (1, 2; STRING)
MISCORE - To be deleted using miscores
Interaction_Type - To be deleted using types
Interaction_Detection_Method - To be deleted using methods
source - To be deleted using sources
Szklarczyk, Damian, et al. "STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets." Nucleic acids research 47.D1 (2019): D607-D613.
Snel, Berend, et al. "STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene." Nucleic acids research 28.18 (2000): 3442-3444.
Updates
V5 2,195,834 edges
V4 1,018,665 edges
V3 1,017,557 edges
V2 1,017,557 edges
V1 1,048,666 edges