SPOKE EDGES

Associated with an adverse response to therapeutic treatment

Evidence for functional interaction of SPOKE compounds with mutant genes.

Describes the impact of human genetic variation on drug responses.

Genes that are genetically associated with a disease.

Genes associated with symptoms.

A Social Determinant of Health (SDoH) can be associated with a disease when conditions in a person's environment (e.g., poverty, lack of access to healthy food, pollution) directly or indirectly contribute to the development, progression, or severity of that disease. These environmental factors can influence health behaviors, stress levels, and access to care, ultimately impacting health outcomes.

The genetic Variant is associated with the Disease.

A haplotype is a group of genetic variations, or polymorphisms, that are inherited together on the same chromosome. This group can encompass one or more genes, and if it includes the variant region of a gene, it can influence how that gene functions.

A Variant can belong to a Gene if it is:
Within multiple genes by overlap
Within the single gene
Near the gene, upstream
Near the gene, downstream
Asserted, but not computed
The genes are overlapped by variant

A Variant belongs to a Haplotype if it is one of the DNA variants that are typically inherited together as a group. Haplotypes are blocks of DNA that are passed down from parents to children without being recombined. When a Variant BELONGS_VbH to a Haplotype, it means that the variant is located on the same Haplotype as other Variants.

A causal mechanism mediated by the direct contact between a compound and a protein, which form a stable physical interaction.

A causal mechanism mediated by the direct contact between a compound and a protein domain, which form a stable physical interaction.

Enzyme catalysis is the increase in the rate of a process by a biological molecule, an "enzyme". Most enzymes are proteins, and most such processes are chemical reactions.

The effect of a drug, other than the desired effect, sometimes in an organ other than the target organ. (NIGMS)

Human-reviewed organism causes disease relationships.

When a protein cleaves to produce a number of polypeptides.

In biochemistry, the substrate is a molecule upon which an enzyme acts. Enzymes catalyze chemical reactions involving the substrate(s).

A blend can contain a compound when that compound is intentionally included as an ingredient in the product's formulation.

A blend can contain a food when that food, or a concentrated or extracted component of it.

A cytoband is a region of a chromosome that is defined based on its unique banding pattern when stained with certain dyes. The CONTAINS_CcG indicates the Gene is contained within the Cytoband region.