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SPOKE EDGES

Starting node type

Ending node type

Relationship tag

Current

ADVRESPONSE_TO_mGarC

Associated with an adverse response to therapeutic treatment

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Current

AFFECTS_CamG

Evidence for functional interaction of SPOKE compounds with mutant genes.

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Current

AFFECT_VaC

Describes the impact of human genetic variation on drug responses.

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Current

ASSOCIATES_DaG

Genes that are genetically associated with a disease.

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Current

ASSOCIATES_GaS

Genes associated with symptoms.

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Current

ASSOCIATES_VaD

The genetic Variant is associated with the Disease.

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Current

BELONGS_HbG

A haplotype is a group of genetic variations, or polymorphisms, that are inherited together on the same chromosome. This group can encompass one or more genes, and if it includes the variant region of a gene, it can influence how that gene functions.

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Current

BELONGS_VbG

A Variant can belong to a Gene if it is:
Within multiple genes by overlap
Within the single gene
Near the gene, upstream
Near the gene, downstream
Asserted, but not computed
The genes are overlapped by variant

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Current

BELONGS_VbH

A Variant belongs to a Haplotype if it is one of the DNA variants that are typically inherited together as a group. Haplotypes are blocks of DNA that are passed down from parents to children without being recombined. When a Variant BELONGS_VbH to a Haplotype, it means that the variant is located on the same Haplotype as other Variants.

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Current

BINDS_CbP

A causal mechanism mediated by the direct contact between a compound and a protein, which form a stable physical interaction.

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Current

BINDS_CbPD

A causal mechanism mediated by the direct contact between a compound and a protein domain, which form a stable physical interaction.

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Current

CATALYZES_ECcR

Enzyme catalysis is the increase in the rate of a process by a biological molecule, an "enzyme". Most enzymes are proteins, and most such processes are chemical reactions.

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Current

CAUSES_CcSE

The effect of a drug, other than the desired effect, sometimes in an organ other than the target organ. (NIGMS)

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Current

CAUSES_OcD

Human-reviewed organism causes disease relationships.

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Current

CLEAVESTO_PctP

When a protein cleaves to produce a number of polypeptides.

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Current

CONSUMES_RcC

In biochemistry, the substrate is a molecule upon which an enzyme acts. Enzymes catalyze chemical reactions involving the substrate(s).

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Current

CONTAINS_CcG

A cytoband is a region of a chromosome that is defined based on its unique banding pattern when stained with certain dyes. The CONTAINS_CcG indicates the Gene is contained within the Cytoband region.

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Current

CONTAINS_FcC

The compounds contained in food.

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Current

CONTRAINDICATES_CcD

A drug can be contraindicated for a disease if it is known to worsen the condition or cause harmful side effects when used in patients with that disease.

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Current

DECREASEDIN_PdD

This protein is decreased in COVID-19.

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